Bust of Max Planck

Highlights

Publication Highlights

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

In sexually reproducing organisms, embryos specify germ cells, which ultimately generate sperm and eggs. In Caenorhabditis elegans, the first germ cell is established when RNA and protein-rich P granules localize to the posterior of the one-cell embryo. Localization of P granules and their physical nature remain poorly understood. Here we show that P granules exhibit liquid-like behaviors, including fusion, dripping, and wetting, which we used to estimate their viscosity and surface tension. As with other liquids, P granules rapidly dissolved and condensed. Localization occurred by a biased increase in P granule condensation at the posterior. This process reflects a classic phase transition, in which polarity proteins vary the condensation point across the cell. Such phase transitions may represent a fundamental physicochemical mechanism for structuring the cytoplasm. C. P. Brangwynne, C. R. Eckmann, D. S. Courson, A Rybarska, C. Hoege, J. Gharakhani, F.Jülicher, A. A. Hyman Science 324, 1729 (2009)
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Publication Highlights

Magnetism: Monopoles on the move

Magnetic materials provide a new context for observing magnetic monopoles. Numerical simulations now establish an experimentally measurable signature of their dynamics - one that has in fact already been seen in a spin-ice compound. R. Moessner and P. Schiffer Nature Physics 5, 250 (2009)
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