Physics of genetic networks: Reliable control of the living cell in the presence of biochemical stochasticity

Stefan Bornholdt

Institut für Theoretische Physik, Universität Bremen, Bremen, Germany

New experimental techniques in molecular biology give a first access to the complex regulatory machinery that controls the living cell. While dynamical models of the full circuitry of the living cell are not available today, mathematical toy models of regulatory processes can help in understanding the construction principles of biochemical regulatory networks. One central question is how a network of regulatory genes can function reliably, despite being constructed from unreliable components as, for examples, small numbers of molecules exposed to thermal fluctuations. We will study possible mechanisms for reliable network dynamics and compare to known biological networks.

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