| Recent results from experiments, bioinformatics and theory indicate a strong impact of spatial genome organization on the machinery of gene regulation. One example is the periodic positioning of certain co-regulated genes on DNA, which is found both for prokaryotes and eukaryotes. We follow the hypothesis that distance minimization in 3D space under a solenoidal epi-organization of the chromosome leads to weight maximization of regulatory interactions. Using Boolean Threshold dynamics, we show that inhomogeneity in interactions ("weak" and "strong" links) increases robustness of regulatory dynamics. Finally, we study the evolution of periodic organization under different mutation operators, and different types of selective constraints. |
|