Dynamic force spectroscopy of single chain-like molecules

Daniel Ebeling

Universität Münster, Center for Nanotechnology (CeNTech), Physikalisches Institut, Münster, Germany

To measure forces acting on a single chain-like molecule during a stretching experiment in liquid, we introduce a dynamic approach based on the frequency-modulation technique with constant-excitation. In difference to the classical approach where the force is recorded as a conventional force vs. distance curve in a static measurement, we are able to detect simultaneously the conservative force as well as the energy dissipation during the elongation of a chain-like molecule.

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