| Control of cell proliferation is a fundamental aspect of tissue physiology central to morphogenesis, normal function and wound healing. Animal morphogenesis, in particular, often proceeds via growth of epithelial monolayers regulated by competing proliferative and inhibitory cues. Although many of the molecular genetic factors are now known, system level coordination of growth, which is necessary to achieve tissue structures of correct size and shape, is still poorly understood. I will present a quantitative characterization of contact inhibition dynamics on tissue-wide and single cell levels. Experimental results are compared to predictions from a tissue mechanics model that takes into account cell-cell coupling and adhesion to the substrate. Finally, the dynamics of cell-cycle re-entry upon release from contract inhibition is discussed. |
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